Clinical manifestations and Disease stage of hypertensive nephropathy

Clinical manifestations

1, severe edema: Edema is often the first symptom was generalized edema, shiatsu depression. Severely ill patient and pleural effusion, ascites, the Dangxiong water, can cause difficulty breathing, umbilical or inguinal hernia more ascites. A high degree of edema, often accompanied by oliguria, hypertension, mild azotemia.

2, proteinuria: massive proteinuria is nephrotic syndrome, the most important performance, qualitative urine protein mostly ~ adult daily urinary protein excretion ≥ 3.5g / d, mostly selective proteinuria.

3, hypoalbuminemia: plasma protein decreased, serum albumin <30g / L, severe cases, less than 10g / L

Hyperlipidemia: blood cholesterol, triglycerides, etc. significantly higher.

Disease staging

, According to the patient's condition and laboratory tests in clinical hypertensive nephropathy is divided into the following phases:

Stage Ⅰ - microalbuminuria: urinary albumin excretion rate anomaly. Normal renal function, urine protein negative;

Phase Ⅱ - clinical proteinuria: urine protein-positive, 24h urinary protein excretion> 0.5g characterized by normal renal function.

Phase III - renal insufficiency period: Ccr decreased, SCr increased characterized. Points of non-dialysis and dialysis period (uremia).

Non-dialysis: Ccr at 40 to 10ml/min, 133μmol / L

Dialysis (uremia): Ccr was <10ml/min. Scr> 707μmol / L.